Protein Details: Voltage-gated sodium channel subunit alpha Nav1.4a
Protein ID
ICDB_Pro_0912
Protein Name
Voltage-gated sodium channel subunit alpha Nav1.4a
Gene Name
scn4aa; nav1.4a
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Length
1829 amino acids
AlphaFoldDB
AF-Q2XVR3-F1-model_v4.pdb
Function
Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting; activated and inactivated states. Required for normal muscle fiber excitability; normal muscle contraction and relaxation cycles.
Sequence
MARLLPPTGTSVFRRFTPESLVEIERLIQEKSTREELEGAEEEPQAPSSDLEAGKCLPMIYGDPPGDLLNTPLEDIDPFYKTQKTFIVISKGNTIFRFSSEPAMFCISPFSIVRRGAIKILIHSLFSMFIMITILSNCVFMTMSNPPAWSKTVEYVFTGIYTFEATVKVLSRGFCIGPFTFLRDPWNWLDFMVISMAYVTEFVDLGNVSALRTFRVLRALKTITVIPGLKTIVGALIQSVKKMIDVMILTIFALAVFALIGLQLFMGNLRQKCIRWPILNSTIFDVYNSNMVNDTTLNVTDTFDFKAYINNEENQYFLEGSLDALLCGNSSDAGRCPEGYTCMKAGRNPNYGYTSYDNFGWAFLALFRLMTQDFWENLFQLTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYDEQNEATLAEARDKEEEFQRLLEQLKNQETGSKASLASQKTQSRGSNRTGSLHDLADEDVIKDCNGRIVPRLIVNRVSSNKELSAEEDQKSLSSKHSMQYLDQPKLSKRTASALSVLTATMEGLEDAQRPCPPGWYKFADMFLKWDCCAPWILFKKWVHFVVMDPFVDLGITICIVLNTLFMAMEHYPMSPHFEHVLSVGNLVFTGIFTAEMVFKLIAMDPYYYFQVGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKISEDCELPRWHMNDFFHSFLIVFRILCGEWIETMWDCMEVAGASMCLIVFMMVMVIGNLVVLNLFLALLLSSFSGDNLSGGDDDGEMNNLQIAIGRITRGIDWVKALVASMVQRILGKKPDNTKEEGEGDIELYALNHLDEGKMADGLTNCLSPTLTVPIARCESDVEEDEDSESSDEEDAKATLNDGDSSVCSTVDYQPPEPEPEPEEVEEEEPEPEEPEACFTEGCIRRCACLSVDITEGWGKKWWNLRRTCFTIVEHDYFETFIIFMILLSSGALAFEDINIERRRVIKTILEYADKVFTYIFIVEMLLKWVAYGFKTYFTNAWCWLDFLIVDVSLVSLTANLMGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIFNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTEERIPMDVVNNKSDCMALMYTNEVRWVNVKVNYDNVGLGYLSLLQIATFKGWMDIMYAAVDSREVDEQPSYEINLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKSKFGGKDIFMTEEQKKYYNAMKKLGAKKRPKPIPRPSNIIQGLVFDFISKQFFDIFIMVLICLNMVTMMIETDDQSAEKEYVLYQINLVFIVVFTSECVLKLFALRQYFFTIGWNVFDFVVVILSIAGLMLSDIIEKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLIMFIFSIFGMSNFAYVKKQAGIDDIFNFETFGGSIICLFEITTSAGWDGLLLPILNSGPPDCDPDFENPGTDVRGNCGNPGMGIMFFCSYIIMSFLVVVNMYIAIILENFNNAQEESGDPLCEDDFDMFDETWEKFDVDATQFIEYDRLFDFVDALQEPLRIAKPNRLKLISMDIPIVNGDKIHSQDILLAVTREVLGDTIEMDAMKESIEAKFIMNNPTSASFEPIITTLRRKEEERAAIAVQRIYRRHLLKRAIRYACFMRRSKRKVRNPNDNEPPETEGLIARKMNTLYGSNPELAMALELETRPMRPNSQPPKPSQVTQTRASVTFPRPQGQLILPVELTSEVILRSAPITHSLNSSENATTIKESIV
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Expressed in skeletal muscle; brain; spinal cord; and eye
DOI ID
10.1007/s00239-005-0287-9; 10.1016/j.cub.2005.10.068
RefSeq
NP_001034914.1